After harvesting the radial artery during CABG, which precaution is necessary to prevent graft spasm?

In the context of coronary artery bypass grafting (CABG) using the radial artery, avoiding graft spasm is crucial to ensure patency and optimal blood flow through the grafted artery. Graft spasm can lead to decreased blood supply to the myocardium and can result in adverse outcomes post-surgery.

The use of perioperative nitrates or calcium channel blockers is essential in this scenario because these medications help relax smooth muscle and prevent contraction in the vascular walls. Nitrates work by increasing the availability of nitric oxide, which leads to vasodilation, whereas calcium channel blockers prevent calcium from entering the cells of smooth muscle, reducing the ability of these muscles to contract. Administering these medications around the time of surgery helps mitigate the risk of spasms in the radial artery graft.

Other options, while they may have their place in different clinical contexts, do not directly address the prevention of graft spasm. Immunosuppressant medication is typically used in organ transplantation rather than in CABG. Skin grafting is not relevant to the prevention of graft spasms and is more associated with wound management following harvest. Lastly, fluid restriction is not pertinent to preventing vascular spasm and could potentially lead to other complications. Thus, the most appropriate and