In postpericardiotomy syndrome, which medication is primarily used for pain relief?

In the management of postpericardiotomy syndrome, nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin are primarily utilized for pain relief. This condition can occur following cardiac surgery, typically presenting with chest pain, fever, and pleuritic symptoms due to inflammation of the pericardium.

Aspirin and NSAIDs address both the pain and the underlying inflammation associated with postpericardiotomy syndrome. They work by inhibiting cyclooxygenase enzymes, reducing the synthesis of prostaglandins, which are key mediators in the inflammatory response. By managing inflammation, these agents can effectively relieve pain and reduce the overall discomfort experienced by the patient.

Choosing corticosteroids could also alleviate inflammation, but they are usually reserved for more severe cases or when patients do not respond adequately to NSAIDs or aspirin, making them not the first-line option for pain management in this context. Opioids, while effective for pain relief, are not the primary choice for this specific condition due to concerns about dependence and side effects. Antibiotics are used to treat or prevent infections but do not play a role in managing the symptoms of postpericardiotomy syndrome.